PI: Loredano Pollegioni

 

Participants:

Silvia Sacchi, Giulia Murtas, Valentina Rabattoni, Zoraide Motta

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Publications:

• Punzo D, et al. 2016. Age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging. J Neurosci. doi: 10.1523/JNEUROSCI.3881-15.2016. 

• Nuzzo T, et al. 2017. Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients. NPJ Schizophr. doi: 10.1038/s41537-017-0015-7. 

• Nuzzo T, et al. 2019. Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity. Exp Neurol. doi: 10.1016/j.expneurol.2019.02.014. 

• Rabattoni V, et al. 2021. Cellular studies of the two main isoforms of human D-aspartate oxidase. FEBS J. doi: 10.1111/febs.15797. 

• Rabattoni V, et al. 2023. On the regulation of human D-aspartate oxidase. Protein Sci. doi: 10.1002/pro.4802. 

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Fundings:

PRIN 2020 (Grant 2020K53E57) to LP

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Collaborations:

• Università degli Studi della Campania "Luigi Vanvitelli"

• Università degli Studi di Milano

• Università degli Studi di Roma "Tor Vergata"

• Consiglio Nazionale delle Ricerche

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